Wednesday, October 17, 2012

Strong Hold on Financial Conflicts --- UC Fictitious Stem Cell Programs and Yudof’s Excuses

Although he is the former chair, Bob Klein should have his rights to speak freely on CIRM (California Institute for Regenerative Medicine) ICOC board meetings, voice his opinions, and advocate for patients. However, Bob Klein is also on ISSCR (International Society for Stem Cell Research) board. That Bob Klein specifically picked Stem Cell Inc - a company of ISSCR former president and CIRM board member - and used his influence as former CIRM chair to successfully lobby $ 40 millions to one single company of his professional association is anything but advocacy for patients. Not only Bob Klein has done it on a public stage, but Bob Klein has also done it by falsifying CIRM grant review statements against scientific evidences. Bob Klein has done it to show the public that CIRM board can award their own financial conflicts of interests against the scientific merits of Prop 71, against the law. Bob Klein has done it to show the public that all the CIRM grant eligibility/review criteria/scores, that have been used by CIRM grant review to stall Prop 71 stem cell research under the public sight, do not apply to CIRM board members’ institutions and companies. Bob Klein has done it to show the public that CIRM board members’ institutions and companies are exempted from the law requirements and scientific merits of Prop 71. Contrary to Alan Trounson’ public comment that there is no evidence for conflicts of interest, Bob Klein has done it by staging a very dramatic public show to provide evidences for conflicts of interest, which is synergized by Alan Trounson’ extraordinarily exceptions that he has given and has given exclusively only to CIRM board members, including Capricor, UCI, and Stem Cell Inc, against the scientific merits of Prop 71 [e.g., none of these awards are for human pluirpotent stem/progenitor cells required by the law/Prop 71]. If these financial conflict evidences are not enough, Ellen Feigal and UC Davis chancellor Claire Pomeroy and Francisco Prieto have also embezzled $50 millions of Prop 71 to a cluster of UC Davis snake oil purveyor against any scientific merits of Prop 71 in one single round of CIRM awards.


University of California (UC)’s firm grip to about half of CIRM awards, total ~ $800 millions from Prop 71 and ¾ of these awards have nothing to do with Prop 71, would not be possible without 12 of their Directors on CIRM board to represent their strong financial conflicts of interest, including Duane Roth, CEO of UC connect; Shlomo Melmed, associate dean of UCLA and director at Cedars-Sinai Medical Center; Robert Birgeneau, chancellor of UC Berkeley; Carmen Puliafito, dean of the Keck School of Medicine; David Brenner, vice chancellor and dean of UCSD; Susan Bryant, vice chancellor of UCI; Sam Hawgood, dean and vice chancellor of UCSF; Claire Pomeroy, vice chancellor of UC Davis; Eugene Washington, vice chancellor and dean of UCLA; Sherry Lansing, a Regent and chair of UC; Francisco Prieto, clinical professor at UC Davis; Oswald Steward, chair and director of UCI. UC’s strong financial interest representation in CIRM board is in staring contrast to UC fictitious stem cell programs/centers where human embryonic stem cell (hESC) research of Prop 71 virtually does not exist. So, without a robust hESC research program, how did Larry Goldstein get ~ $30 million awarded to himself from CIRM without having to do anything? With ~ $800 millions of taxpayers’ money that is enough to jump start many robust competitive hESC research programs or Regenerative Medicine start-ups, why would UC shut down hESC research labs (see below UC president Yudof’s excuse)? With mass amount of empty research spaces to offer, why could not UC, the biggest beneficiary of Prop 71, accommodate hESC research (see below UC president Yudof’s excuse)?


CIRM has awarded $1.2 billion out of 1.6 billion to those without Prop 71 scientific merits using a flawed grant review process that has zero implementation for Prop 71, even hostile to Prop 71 stem cell research. Who are selecting those biased CIRM awards using their CIRM sponsored meetings & CIRM board conflict of interest connections? What the public may not know is the despotic power of those professors as stem cell program/center directors acting on their financial conflicts of interest. As we know, Larry Goldstein had lots of talks about his fictitious astrocytes for > $10M CIRM ALS award with virtually no results [e.g., not even a single piece of data to show his cells express astrocyte markers in his ~ 1 hr on stage talk at world stem cell summit, he admitted himself publicly not working for ALS either]. And Larry Goldstein’s professional associate Anjana Rao, an immunologist and impostor for other stem cell scientists in San Diego UT, has cheated $Ms from CIRM with her fictitious stem cell research just because of her close connection with Larry Goldstein. With their tens of millions of financial benefits at stake, how likely do you think Larry Goldstein’s meeting committee for Stem Cell Meeting on the Mesa (SCMOM) would be able to perform any unbiased activities for scientific presentation? Both Anjana Rao and Larry Goldstein have $ Ms of CIRM awards for their fictitious stem cell research that has virtually no stem cell research results, no wander SCMOM cannot accommodate hESC research advances (see below poster submission for SCMOM). SCMOM’s hostile to hESC research is evident if check their invited list selected not based on the sciences but based on financial conflicts of interests with their senior organizers, committee members, directors, and close professional associates, so meeting organizers’ and CIRM board members’ close professional associates would be well accommodated for hundreds of millions of awards.


Sanford Consortium for Regenerative Medicine (SCFRM) is built with public stem cell research fund and supposed to open to all stem cell researchers in San Diego, open for collaboration, open for stem cell research advances. However, a year after the grand opening of "collaboratory", it remains as their senior directors’, such as Evan Snyder and Larry Goldstein, extended definition/territory for their own labs for the sole benefit of their institutes’ financial interest. Inconsistent to their deceptive idol-like faces in public, those directors’ un-collaborative behavior acting on their real financial conflicts of interest is nothing unfamiliar. Did I hear that Jean Loring claimed to sue Burnham officials if I would ever gain access to Burnham stem cell center supported by NIH funding that I was a major contributor to get that NIH center grant when I was at Burnham? Did I hear that Larry Goldstein claimed that I was not allowed to use UCSD stem cell center when I was at UCSD? Did I hear that Larry Goldstein used his despotic power as UCSD stem cell director to send mass emails to UCSD chancellor, deans, faculty to threat anybody who would give me a faculty position and lab spaces to allow me to administrate my NIH grants on human embryonic stem cell research, while he claimed himself publicly as a stem cell scientist, stem cell director, and supportor of hESC research?


Like SCMOM, Vincent Chen is just another episode of such severe conflicts of interest with those in power and abuses that power; either as director, mentor, or senior collaborator. Looking back on my mentor research scientist career development award (NIH K01 AG024496) in a field so controversial so money-driven, I would like to record here those examples of conflicts of interest that I wish it would be otherwise,
Conflicts of interest example 1: PI’s senior mentor Dr. Jean Loring had her close friends in or connected to NIH grant review committee [e.g., Mahendra Rao, former NIA & Director of CRM in NIH] to put the critique in summary statement to have the PI to identify her as the specific senior mentor for her K01 award. Dr. Jean Loring had financial or other interest in Dr. Parsons’ research/application, as evidenced by that she was able to use her advantages in senior position and resources to claim credits, including authorship & grants, for PI’s stem cell research, and was promoted to Professor & Center Co-Director at Sanford Burnham Medical Research Institute (former Burnham Institute) and received ~ 3 millions stem cell center grant from NIH without having to put the PI on the center grant. In fact, Dr. Loring used her advantage senior position as professor & stem cell center co-director to exclude the PI from using NIH-funded stem cell center resource for her stem cell research. Dr. Jean Loring has never fulfilled any mentor responsibility as written in her mentor support letter to NIH, and has used her advantages in senior/director position and resources to prevent the PI from fulfilling the career goal of K01 award to become an independent investigator or assistant professor/faculty due to conflicts of interest.

Conflicts of interest example 2: PI’s senior mentor Dr. Evan Snyder has financial or other interest in Dr. Parsons’ research/application, as evidenced by that he was able to use his advantages in senior position and resources to claim credits for all PI’s stem cell research, and was promoted to Center Director at Sanford Burnham Medical Research Institute (former Burnham Institute) and received ~ 3 millions stem cell center grant from NIH without having to put the PI on the center grant. In fact, Dr. Evan Snyder has used his advantages in senior mentor/director position to claim credits, including authorship and grants, for PI’s stem cell research, such as multi-millions of CIRM and NIH grants, collaboration/contracts with other senior collaborators, alliance and consortium, and donations or sponsorship/partnership from foundations and big Pharms, on which he has never included the PI or he has never obtained any collaboration agreement or consent from the PI. Dr. Evan Snyder has never fulfilled any mentor responsibility as written in his mentor support letter to NIH, but has spent >$30,000 of PI’s K01 award for his own lab use (although he was not supposed to according to K01 contract). Dr. Evan Snyder has used his advantages in senior/director position and resources to prevent the PI from fulfilling the career goal of K01 awards to become an independent investigator or assistant professor/faculty due to conflicts of interest.  

Conflicts of interest example 3: PI’s senior mentor Dr. Stuart Lipton has financial or other interest in Dr. Parsons’ research/application, as evidenced by that he was able to use his advantages in senior mentor/director position and resources to claim credits, including authorship and grants, for PI’s stem cell research, such as NIH center grants (e.g., Burnham NIH PD center) and multi-millions of CIRM grants, collaboration/contracts with other senior collaborators, alliance and consortium, and donations or sponsorship/partnership from foundations and big Pharms, on which he has never included the PI or he has never obtained any collaboration agreement or consent from the PI. In fact, Dr. Stuart Lipton has never fulfilled any mentor responsibility as written in his mentor support letter to NIH. Dr. Stuart Lipton has used his advantages in senior/director position and resources to prevent the PI from fulfilling the career goal of K01 awards to become an independent investigator or assistant professor/faculty due to conflicts of interest.  

Conflicts of interest example 4: PI’s senior mentor Dr. Yang Xu has financial or other interest in Dr. Parsons’ research/application, as evidenced by that he was able to use his advantages in senior position and resources to claim credits for PI’s stem cell research, and was promoted to Professor at University of California at San Diego. In fact, Dr. Yang Xu, who lacks appropriate stem cell research expertise, has used his advantages in senior mentor position and resources to claim credits for PI’s stem cell research for multi-millions of CIRM grants, on which he has never included the PI or he has never obtained any collaboration agreement or consent from the PI. Dr. Yang Xu has never fulfilled any mentor responsibility as written in his mentor support letter to NIH, but has used his advantages in senior position and resources to prevent PI from getting promotion/faculty position & research/lab spaces in UCSD to administrate her NIH grants, and has spent ~ $50,000 of PI’s K01 award for his own lab use (although he was not supposed to according to K01 contract). Dr. Xu has used his advantages in senior position and resources to prevent the PI from fulfilling the career goal of K01 awards to become an independent investigator or assistant professor/faculty due to conflicts of interest.  

Conflicts of interest example 5: PI’s senior mentor Dr. Prue Talbot, who lacks appropriate stem cell research expertise, has financial or other interest in Dr. Parsons’ research/application, as evidenced by that she was able to use her advantages in senior/director position and resources to claim credits for PI’s stem cell research to get multi-millions of CIRM grant funded as UCR stem cell director, on which she has never included the PI or she has never obtained collaboration agreement or consent from the PI. In fact, Dr. Prue Talbot has never fulfilled any mentor responsibility as written in her mentor support letter to NIH, but has involved in shutting down of PI’s hESC research lab at UCR and holding PI’s stem cells and research equipments in UCR without license agreement due to conflicts of interest. Dr. Talbot has used her advantages in senior/director position and resources to prevent the PI from fulfilling the career goal of K01 awards to become an independent investigator or assistant professor/faculty due to conflicts of interest. 

Sunday, October 14, 2012

Frenzy over Reprogramming --- Nobel Prize Condescended to Cooked Stem Cell Fraud


The frenzy over induced pluripotent stem cells (iPS cells) in last few years was finally topped by Monday’s Nobel Prize announcement to most disbelief, which shows that the Nobel committee is only human and makes mistakes too. It is the sad consequence of irresponsible research from a combination of failure in knowledge, scientific conduct, originality, and peer review. It is the cooked result from lack of open discussion & dialogue, transparency, open public policy & view & opinion, open & unrestricted scientific ground, and open mind. It is ISSCR (International Society for Stem Cell Research) and few well-connected big names’ forced monologue cooked to appeal the political need and interest of opponents of human embryonic stem cell (hESC) research. It is erosion of scientific integrity and public trust. It is degraded of sciences and Nobel Prize. It does not take a genius or a Nobel committee to tell iPS cell is fraud. Yamanaka did not have any scientific data for the normality and stability of iPS cells that have been used to differentiate normal stem cells from abnormal cancer cells when it was rushed to publish in Cell, so it would come in handy for the political climate of Bush Administration and for those against hESC research to stall human embryonic stem cell research. Yamanaka even proved himself that DNA integrity is damaged and DNA damage check is compromised in iPS cells, so iPS cell is a hoax and he is irresponsible. So far, there is no scientific evidence that iPS cells are stem cells, nor iPS cells can cure any disease or be used for medicine, nor Yamanaka generated any cells work for any diseases for any imminent clinical trial. Far cry from 2010 when Nobel committee gave the IVF pioneer Robert Edwards his well–deserved Nobel Prize recognition, in 2012, Nobel committee has condescended to give Nobel Prize to the biggest stem cell conman. See our previous posts. Also See california stem cell report and Knoepfler stem cell blog for other opinions.